Center to center distance is one thing, belt alignment is an entirely different beast.
The centerline of the crankshaft and the centerline of the trans input shaft MUST be perfectly parallel to each other in both the "looking down from the top of the machine" and the "looking at the machine from the back" points of view. Call it X and Y axis if you understand the three dimensional Cartesian Coordinates system - Z axis would be looking down the afore mentioned center lines. (c/l)
Looking from behind, if the c/l's are not parallel, you are introducing a slight twist into the belt and it will cause heat buildup and wear on the clutch faces and belt.
Looking down from the top, if the c/l's are not parallel, it loads the belt on one side, once again causing heat buildup and wear on the clutch faces and belt. This misalignment is the worst of the two.
It will also affect clutch action/performance, as they are designed to be actuated in a perpendicular to c/l input, so the moment you twist or misalign, you introduce a side loading that they're not tolerant of and this leads to premature wear of the sliding parts and surfaces in the clutches - mainly the secondary (driven) clutch.
My first desert race car ran a cvt setup that would smoke a belt after long, high speed runs. Turned out that the alignment was out as looking down. As long as I varied speed, making the belt move up/down in the sheaves, not building heat in one spot, I could combat belt loss but it was a temporary fix. Once I realigned the system, I never had another belt failure other than wear.
Clutch alignment is probably one of the most critical aspects of tuning in any CVT system and probably the most overlooked.